![]() ![]() It also offers the unique P-AST, a phenotypic AST test that also assesses the influence of polymicrobial interactions on drug resistance. Pathnostics' Guidance UTI tests for 30 organisms and 32 antibiotic resistance genes with 6 antibiotic classes. There are slight nuances to each product, which might lead to choosing 1 over another. 5 Among women who ordered the home detection PCR tests, there are high satisfaction rates, with 86% of participants opting for this modality again. In comparative studies, M-PCR outperforms SUC with polymicrobial speciation and detection of specific gram-positive bacteria (ie, mycobacteria and aerococcus).20 Uropathogen detection among symptomatic women appears to be higher, with 96% PCR positive vs 81% SUC positive. All include phenotypic results for AST, whereas some offer more sophisticated pooled-AST (P-AST) (Pathnostics Guidance UTI).17-19 Within 24 to 48 hours, patients will have a diagnosis, antibiotic resistance information, and AST. Commercially available products exist that identify urine pathogens and screen for antibiotic resistance genes, including SolarisDx’s UTI ID Panel, Genetworx’s UTI Molecular PCR Test, and Pathnostics’ Guidance UTI. ![]() 16 More recently, PCR testing was expanded to UTI, where utilization is growing with different LDTs. 8 LDTs are in-vitro tests offered by a single laboratory that are not regulated by the FDA. 8 PCR testing is utilized in numerous clinical settings, including sexually transmitted diseases, respiratory illness, and gastrointestinal infections, using both FDA-approved and laboratory developed tests (LDTs). 8 Multiplex PCR (M-PCR) allows for the identification of numerous DNA sequences at the same time. PCR testing involves the amplification and then detection of targeted DNA sequences from microorganisms at low concentrations. 11-15 For these reasons, newer technologies, such as polymerase chain reaction (PCR) testing, have been developed to aid in the diagnosis of UTI. 10,11 This adds significant complexity to balancing the under- and overdiagnosis of UTI, but it also aids in better understanding the polymicrobial nature of UTI, pathologic microbiomes, and the creation of facultative resistant biofilms. 7-9 Lastly, it is established that a urinary microbiome exist. ![]() Does not include assessment for fastidious, anaerobic, and fungal biota, which requires additional time and cost. ![]()
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